Senior Scientist, DMPK

Bicycle Therapeutics

Cambridge, United Kingdom

Job Description

The Senior Scientist of Drug Metabolism and Pharmacokinetics (DMPK) reports to the Senior Director, DMPK. They will be responsible for coordinating DMPK experiments, interpreting and presenting data to drug discovery project teams.

Key Responsibilities

Co-ordinate experiments with CRO’s;
Review, interpret and report data in support of drug discovery projects;
Present data at multifunctional project teams;
Work collaboratively with other core disciplines within a project team to support smooth and timely progression of compounds through the drug discovery cascade;
Integrate data from multiple sources to inform the understanding of bicyclic peptide distribution, metabolism and excretion.

Qualifications

BSc in relevant scientific discipline such as drug metabolism, pharmacology, pharmaceutical sciences;
In depth understanding of DMPK science;
Working knowledge of multiple DMPK/ADME assays including ability to trouble-shoot;
Good knowledge, obtained from hands-on experience, of interpreting LCMS data from in vitro and in vivo experiments;
Experience working on drug discovery and/or development projects as a DMPK representative;
Excellent organisation and communication skills, both written and oral, confident presenting data;
Hands-on experience of PK data analysis software packages to conduct non-compartmental analysis;
Hands-on experience in in vitro-in vivo extrapolation (IVIVE), PK/PD, and/or physiologically based pharmacokinetic (PBPK) modeling preferred;
Experience working on radiopharmaceuticals or peptides would be an advantage;
Experience using Dotmatics would be an advantage.

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