Senior DMPK Scientist as Project Representative

AbbVie

Ludwigshafen, Germany

Job Description

The QTAS (Quantitative, Translational & ADME Sciences) department in Ludwigshafen is seeking for an experienced senior scientist with DMPK background to support Discovery Projects as a QTAS Project Representative. As the successful candidate, you will contribute to advancing our small molecule pipeline by managing the characterization and selection of potential drug molecules mainly for Neuroscience indications throughout Discovery and early Development stages. To this end, you will serve as a primary contact for cross-functional project teams to adress questions and share knowledge across the fields covered by the QTAS department (e.g. ADME, PK, PK/PD, BA, Biomarker), and you will provide expert opinion for decision-making to ensure pipeline progression.

Your Key Responsibilities:

Serve as a QTAS representative on multidisciplinary project teams supporting the development of novel small molecules; collaborate with project team members (e.g., discovery, toxicology, clinical pharmacology) and groups within QTAS to generate relevant data guiding target validation, compound characterization, and candidate selection;
Develop and drive the QTAS strategy for small molecule discovery, preclinical, and clinical development of projects to support decisions and milestone transitions;
Effectively communicate QTAS strategy and knowledge to project teams, functional leaders, and other key stakeholders to ensure alignment and influence decisions;
Demonstrate thorough understanding of ADME sciences and PK/PD aspects necessary to optimize drug candidates;
Coordinate and request ADME, PK and PK/PD studies in a timely manner and communicate protocols, timelines, needs and results back to team, ensuring optimized cycle times;
Integrate ADME, PK, PK/PD data with discovery biology data and provide thought leadership to project teams as a functional representative;
Prepare QTAS sections of regulatory submission documents (IND, IB, NDA); provide responses to regulatory questions and ensure generation of appropriate reports;
Mentor junior project reps;
Manage external projects/studies with CROs and in collaborations with universities.

Qualifications

Your Profile:

Bachelor’s Degree or equivalent education and typically, 12 years of experience, Master’s Degree or equivalent education and typically 10 years of experience, PhD and typically 4 years of experience n Biology, Biochemistry, Pharmaceutical Sciences, or related area;
Multiple years of experience independently representing DMPK/QTAS function on small molecule project teams is required;
Deep expertise in at least one discipline of DMPK, coupled with a broad knowledge of general ADME principles. Strong understanding of Drug Metabolism, PK, PK/PD modeling, human PK and DDI prediction strategies;
Knowledge in the field of neuroscience is a plus;
Expertise with peptides, or with a variety of small molecule modalities such as degraders and covalent binders, or with biologics, in addition to a strong expertise with classical small molecules is desired;
Passion for data analysis, interpretation and presentation;
Demonstrated scientific leadership, guiding scientific investigative strategies to an effective and productive outcome;
Ability to influence, negotiate and communicate effectively with both internal and external stakeholders; ability to work well in a collaborative fast-paced team environment;
Highly motivated, self-driven and results-oriented person with excellent communication and presentation skills, capable to work both as a team player within a multi-functional group and as a driver of projects and initiatives;
High degree of flexibility in adapting to different projects and people; excellent networking and relationship-building (both internal and external) skills;
Fluency in English is a requirement, German language skills are beneficial.