Principal Scientist, In vivo Pharmacology (Radiopharmaceuticals)
Bicycle Therapeutics
Cambridge, United Kingdom
Job Description
Bicycle Therapeutics is seeking a talented scientist with strong experience of in vivo radiopharmaceutical evaluation to support the preclinical research and discovery efforts for our expanding portfolio of Bicycle -based therapeutics.
You will have a passion for developing transformational treatment paradigms for cancer patients and will enjoy working collaboratively across programs.
This position will report to the Associate Director of In vivo Pharmacology.
Key Responsibilities
- Manage the design, execution and interpretation of results from in vivo pharmacology studies to evaluate the activities of Bicycle® Radio Conjugates (BRC™);
- Manage in vivo pharmacology research through a network of CROs and academic collaborations;
- Effectively collaborate with cross functional disciplines (biology, DMPK, translational sciences, toxicology) and engage internal stakeholders to drive decisions;
- Effectively document and communicate results company-wide in diverse settings ranging from project team meetings to internal L&D scientific forums (e.g. science spotlight)
- Lead in vivo pharmacology sample management;
- Author publications in peer-reviewed journals and represent Bicycle at conferences with scientific presentations in poster or oral formats.
Qualifications
- Educated in biological sciences field with extensive industrial experience;
- Hands-on experience using multiple types of in vivo oncology models is required;
- Experience in the evaluation and development of radiopharmaceuticals is desired;
- Experience in radiochemistry and radiolabeling of compounds would be preferred;
- Experience in pre-clinical biodistribution and efficacy assessment of radiopharmaceuticals using techniques such as PET and/or SPECT imaging, and ex-vivo biodistribution is required;
- A working knowledge of dosimetry would be an advantage;
- Some experience in managing external work/collaborations is preferred;
- A strong background in cancer biology is preferred;
- Capability of working both independently and as part of multiple collaborative and multidisciplinary teams;
- Attention to detail and strong interpersonal, organizational and communication skills;
- Innovative, entrepreneurial, enjoys working in a fast-paced, small-company environment.
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