Senior Pharmacokineticist

Evotec

Verona, Italy

The aim of this role is to perform all types of pharmacokinetic and pharmacodynamic analysis (PK/PD) e.g. non-compartmental PK, compartmental and population PK and PK/PD, to support clinical studies, including translational PK/PD analysis.

Qualified candidates will have the ability to work on a variety of therapeutic indications and data types with an adequate understanding of applied population PK and PK/PD modeling and simulation to support drug development programs.

Key Responsibilities

Plan and perform appropriate analysis (e.g. non-compartmental, population and/or modeling and simulation analysis of PK and/or PD data) of clinical data, dose/exposure-response relationships, to guide dose regimen and optimize study design;
Summarize and provide interpretation of results of PK and PK/PD analyses with respect to their impact on a development program and clinical use;
Development of translational PK/PD models to support clinical studies;
Work closely with multidisciplinary project teams to develop and implement semi-mechanistic mathematical models of pharmacological processes;
Carries out functional responsibilities in accordance with applicable SOPs, regulatory requirements (GLP and GCP) and company Policies, maintaining high level of quality and reliability in all work conducted;
Provide scientific and operational support to Clinical PK capabilities expansion, including human dose/PK prediction strategies and advanced clinical PK.

Technical Competencies, Education and skills

MSc in pharmacology, bio/engineering, pharmacokinetics/pharmacodynamics, Mathematics or equivalent disciplines;
PhD in relevant discipline (pharmacology, bio/engineering, pharmacokinetics/pharmacodynamics, etc.) will be considered as a plus;
A minimum of 1 to 3 years of industry/consulting experience (may be combined with academic research) working in R&D, pre-clinical and clinical environments;
Experience in using modelling and simulation packages such as Monolix, R, NONMEM;
Proficiency in software used for clinical non-compartmental analysis (NCA) - Phoenix Winnonlin;
Proficient in spoken and written English;
Knowledge of PBPK models and use of PBPK software (e.g. Gastroplus, PKsim) will be considered as a plus;
Machine leaning knowledge will be considered as a plus;
Provide scientific and operational support to Clinical PK capabilities expansion, including human dose/PK prediction strategies and advanced clinical PK;
Excellent communication skills, both written and oral;
Excellent problem-solving capabilities and organizational skills.