Associate Director, DMPK

Bicycle Therapeutics

Cambridge, United Kingdom

Job Description

The Associate Director of Drug Metabolism and Pharmacokinetics (DMPK) reports to the Vice President of Quantitative Pharmacology group. In partnership with drug discovery medicinal chemists and pharmacologists, they will be responsible for representing DMPK, designing and executing non-clinical studies in support of multiple projects from target identification through to candidate selection and ultimately regulatory submission.

Design and implement the appropriate DMPK strategy according to the stage and needs of a project;
Design experiments, review, interpret and present data at multifunctional project teams;
Perform DMPK activities including interactions with external CRO’s and internal project stakeholders;
Work collaboratively with other core disciplines within a project team to support compound progression based on optimizing DMPK properties;
Integrate data from multiple sources to inform the understanding of bicyclic peptide distribution, metabolism and excretion;
Work closely with in-vivo pharmacology, toxicology and/or clinical pharmacology to design experiments to understand preclinical pharmacokinetic/pharmacodynamic (PK/PD) relationships and enable human efficacious dose projection;
Track DMPK budgets for CRO’s and contribute to project spending forecasts.

Qualifications

MSc/PhD in relevant scientific discipline such as drug metabolism, pharmacology, pharmaceutical sciences;
Experience working on DMPK drug discovery and/or development projects as a DMPK representative with a track record of problem solving and successful delivery across drug discovery;
In depth understanding of DMPK science with additional knowledge of related disciplines;
Ability to adapt your working style to suit different cultures and partner expectations in both remote and office-based environment;
Excellent organisation and communication skills, both written and oral, with the ability to influence;
Hands-on experience in in vitro-in vivo extrapolation (IVIVE), PK, PK/PD, and/or physiologically based pharmacokinetic (PBPK) modeling preferred;
Experience supporting radiopharmaceutical projects desirable;
Experience working on peptides or macrocycles would be an advantage;
Experience using Dotmatics would be an advantage.

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