Associate Scientist

Associate Scientist

Gilead

Oxford, United Kingdom

Role Purpose:

To contribute to the design and development of novel protein therapeutics, which will support early research all the way through to lead candidate nomination for pre-clinical studies.

Key Responsibilities:

• Utilize molecular biology cloning strategies to design, engineer, and express proteins and antibodies of interest
• Recombinant protein expression/production, predominantly using mammalian platforms, using small-scale expression processes through to large-scale preparations (e.g., affinity chromatography, and prep-SEC using ÄKTA purification systems)
• Biophysical characterisation of proteins using SDS-PAGE, HPLC, and DLS, and functional characterisation using BLI and SPR
• Engineer proteins and antibodies for lead therapeutic identification and downstream clinical development
• Analyze and troubleshoot experimental data to support pipeline progression
• Stay updated with scientific literature and advances in protein engineering to incorporate best practices into your work

Ideal Qualifications:

Minimum Education & Experience:

• BSc or MSc degree in Molecular Biology or Biochemistry (or a related discipline) with hands-on laboratory experience
• Proficiency in molecular cloning techniques and experienced in mammalian cell culture and recombinant protein expression
• Experience with protein design, production, and biophysical characterization, including SPR

Skills and Attributes:

• Strong analytical and practical skills, with high attention to detail demonstrated through academic or research achievements
• Self-motivated and enthusiastic about solving problems and contributing to project pipelines
• Team player with excellent collaboration skills and experience working in multidisciplinary teams
• Effective written and verbal communication skills
• Flexible and adaptable to shifting priorities, with a demonstrated ability to learn quickly in a fast-paced research environment.

Desirable Experience:

• Familiarity with sequence analysis or molecular biology software
• Exposure to development of protein expression, purification, and biophysical characterization workflows
• Familiarity with approaches to molecular modelling, particularly relating to the design and optimisation of antibody sequences

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