Discovery Safety Scientist

Discovery Safety Scientist

Evotec

Multiple Locations

Main Responsibilities will include

• Responsible for the scientific oversight of discovery toxicology studies conducted across multiple projects at Evotec
• Analyse, interpret and present toxicology data to project teams, updating risk assessments and applying knowledge and experience to impact project decisions
• Develop and oversee target de-risking strategies for new projects based on the outcomes of target safety assessments
• Provide timely safety/toxicology guidance to project teams at all stages of the drug development process
• Provide project teams with an understanding of the predictivity of in silico and in vitro toxicology methods, their translatability in vivo and the associated clinical impact
• Bridge the gap between discovery and development toxicology, allowing more consistency and streamlining of processes that affect project progression
• Keep up to date with the latest NAMs and their potential to impact current paradigms at Evotec

Knowledge and Experience

• Significant and varied experience working in the field of toxicology, with a detailed working knowledge of at least one area of discovery toxicology
• Sound knowledge of designing and delivering nonclinical safety development strategies for small molecules and biologics in the pharmaceutical industry
• Experience in experimental design and data interpretation of early safety studies and their translatability relating to drug development
• Working knowledge of GLP regulations, ICH, OECD, FDA, EMA and other regulatory guidelines, and their application to the design of appropriate non-clinical safety studies
• Knowledge of early target safety assessments with a focus on target de-risking strategies using bespoke or globally accepted in vitro techniques
• Strong organisational and communication skills
• Ability to work under pressure, manage multiple projects and deliver to defined timelines
• Familiarity with working within small and large molecule drug discovery programs as a nonclinical safety representative with a basic understanding of associated disciplines, e.g. biomarkers, DMPK, biology, medicinal chemistry
• Knowledge of predictive in vivo toxicology studies routinely performed during early phases of drug development
• Awareness of in silico toxicology and how predictions can guide risk strategies for project teams

Education and Qualifications

• BSc or higher in a relevant scientific discipline such as toxicology, pharmacology, etc.
• DBAT/ERT/UKRT certification desirable

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