Senior Scientist Biochemistry and Structural Biology

Senior Scientist Biochemistry and Structural Biology

Grünenthal Group

Aachen, Germany

What the job looks like

Each day you’ll enjoy a variety of challenges, such as:

• Generate impactful biochemical, biophysical, and structural biology data with human relevance to support our small molecule- and genetic medicine projects;
• Explore target mechanisms, propose and evaluate novel targets;
• Propose internal programs and represent Biochemistry and Structural Biology in cross-disciplinary project teams;
• Explore and supervise external collaborations with academia, biotech companies and contract research organizations in the field of Biochemistry, Biophysics and Structural Biology;
• Ensure high quality experimentation (both internal and external), analysis, and data management;
• Foster open and clear communication across different functions.

What you’ll bring to the table

To make the most of this role and truly thrive, you should have:

• A PhD in biochemistry or structural biology or a closely related discipline with a minimum of 5 years’ work experience in an industrial drug discovery setting;
• Proven ability to independently design and safely execute wet lab experiments;
• Experience and proven track record in the development and use of biochemical assays to study different molecular target classes (e.g. ELISA assays, biomarker detection, protein purification, protein-protein or protein-ligand interactions, protein turn over, enzymatic assays, capillary-based immunoassays and automated Western blot analysis);
• Experience in biophysical and structural biology techniques (e.g. surface plasmon resonance, microscale thermophoresis, spectral shift, differential scanning fluorimetry, dynamic light scattering, calorimetry, x-ray crystallographic analysis, cryo-electron microscopy);
• Experience with RNA-modulating therapies (e.g. ASO, siRNA) incl. targeted delivery is an advantage;
• A passion for investigating molecular mechanisms and exploring targets with a good understanding on how targets/pathways can be modulated in pain, neuroscience or adjacent disease areas;
• Ability to set up novel techniques in a result-oriented manner and challenge the status quo with an open mind;
• Pragmatic, optimistic, problem-solving attitude with natural curiosity; someone who will reach out proactively, internally and externally, to source alternative solutions;
• Excellent mathematical skills and data analysis capabilities with a drive for data quality and high-quality documentation;
• Excellent organizational and communication skills with a high level of team spirit.

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