Associate Researcher Drug Product and Analytical

ProQR Therapeutics

Leiden, Netherlands

Our Chemistry, Manufacturing and Control (CMC) Department is currently looking for an Associate Researcher, (Full-time) to join our team in Leiden. We are looking for candidates with a passion for analytical and formulation work. This role would suit a recent graduate with a background in analytical chemistry or related disciplines. The CMC department has a central role within the ProQR Therapeutics organization. The CMC Department develops, manufactures, and characterizes oligonucleotides and therapeutic formulations for research, clinical development, and commercialization.

The Role:

The Associate Researcher will execute in-house lab activities in both the Drug Product and the Analytical teams, which are part of the CMC department. The successful candidate will work closely with other researchers/scientists in an interdisciplinary team environment to help with all activities related to formulation and analytical testing, in support of oligonucleotide manufacturing:

Preparation of simple and complex formulations to provide the research material;
Execution of analytical tests (Bacterial endotoxin, pH, Osmolality, UV spectroscopy, mass spectrometry, DLS, bacterial endotoxin);
Perform proper documentation and accurate record-keeping of experimental data;
Support preparation of technical protocols and reports;
Support the preparation, or revision, of standard operating procedures (SOPs);
Support general lab activities such as equipment maintenance and inventory management.

We expect our Associate Researcher to have:

Bachelor’s degree in analytical chemistry (HLO/HBO), organic chemistry, biochemistry, biopharmaceutical sciences or related scientific discipline with 0-2 years experience;
Strong laboratory skills and a high degree of attention to detail;
Good understanding of formulations, and hands-on experience in preparation of material for in vitro and in vivo experiments;
Good understanding of, and hands-on experience with, analytical techniques such as UPLC or HPLC, mass spectrometry, pH, bacterial endotoxin, osmolality, DLS and UV-Vis spectroscopy;
Proficient in spoken and written English;
A responsible person with a proactive attitude who can work independently;
Being flexible, analytical, and well-organized;
A team player.

Preferred:

Experience with Waters HPLC software is preferred;
Experience with GMP;
Should enjoy challenging situations and have the flexibility to work in a dynamic and fast-moving environment where there is the freedom to act.

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