Lead Scientist R&D Process Development

Lonza

Slough, United Kingdom

The purpose of the role is to maintain Lonza Pharma & Biotech as a leading contract manufacturer through the development and optimization of fed-batch and perfusion process technologies at lab scale employing automation engineering solution.

Key responsibilities:

Working closely with the upstream R&D team; plans and executes several complex (non-routine) lab-scale fed batch and perfusion bioreactor process development and optimization experiments
Experience with mechanistic modelling for CHO cell bioprocessing
Set up, operate, and maintain lab-scale bioreactors for mammalian cell culture. Monitor bioprocess parameters and ensure optimal conditions for cell growth and productivity
Support setting automated sampling (integrating the process analytical instruments at-line) and integrating the upstream and downstream towards a continuous manufacturing process
Generates experimental results and reviews respective scientific documentation
Is responsible for ensuring that studies are scientifically sound and in line with current regulatory guidance and expectations
Helps with ensuring lab procedures are adhered to and supports safety assessments
Design, develop, and implement automated systems to optimize upstream bioprocessing workflows
Collaborate with cross-functional teams to understand process requirements and translate them into efficient automation solutions
Work in close collaboration with IT/OT/Network Infrastructure and Security Teams to ensure a reliable and secure automated manufacturing environment
Support updates to and maintenance of data historian systems
Complying with the required relevant Lonza training
Perform other duties as assigned

Key requirements:

EngD/PhD/MSc/Meng/Field of Study: Bioprocessing/Chemical Engineering/Biotechnology or similar field
In depth knowledge in lab-scale bioreactor control and upstream process development for mammalian cells with 4-5 years of experience.
Experience with mechanistic modelling for CHO cell bioprocessing
A strong background in mammalian cell culture
Knowledge of perfusion techniques and know how to develop new manufacturing processes to produce next generation antibodies
Familiarity with PAT (Process Analytical Technology) tools and analytical techniques (Tridex, Octet) are a plus
Demonstrated innovative skills and experience with leading complex technology projects
High level of communication and presentation skills

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