(Senior) Scientists - Medicinal Chemistry

Selvita

Krakow or Poznan, Poland

As a Medicinal Chemist, you'll play a vital role in the process of drug discovery projects, helping to create new and more effective medicines. Using a range of chemistry techniques and data analysis tools, you'll design and create new pharmaceutically active molecules to combat a particular disease or condition. You'll be working in a collaborative environment within a project team of scientists to understand and interpret the results of biological testing of the compounds that have been created. You'll also use the results of these tests to improve molecules until there is sufficient evidence that the selected molecule can be efficacious and safe for testing in people.

Join us at Selvita, where these values guide our mission to advance drug discovery to the clinical stage of drug development.

Key responsibilities

Design and synthesize new pharmaceutically active molecules to address specific diseases or conditions;
Utilize a range of chemistry techniques and data analysis tools in the drug discovery process;
Collaborate with project teams of scientists to interpret and understand biological testing results of synthesized compounds;
Use the biological testing data to refine and optimize molecules for efficacy and safety;
Ensure the selected molecules meet the necessary criteria for further preclinical testing;
Conduct laboratory work, ensuring adherence to safety protocols and experimental procedures;
Contribute to project planning and strategy discussions to guide drug discovery efforts;
Maintain detailed and accurate records of experiments, results, and progress reports;
Present research findings to internal teams and external partners;
Stay updated on advancements in medicinal chemistry and integrate new methodologies into research activities.

Your background

A Ph.D. or MSc degree in medicinal chemistry or organic chemistry;
Written and verbal proficiency in the English language is required;
Post-educational experience working in the drug discovery environment, preferably in large biotech or medium/large Pharma company;
Experience in the drug discovery process from hit-to-lead, lead optimization, up to the stage of clinical candidate nomination;
Deep knowledge of modern synthetic organic chemistry;
Familiarity with modern computational chemistry approaches;
Understanding of the biological basis of compound activity for selected indications;
Awareness of modern screening technologies;
Good understanding of in vitro and in vivo pharmacokinetic principles;
Experience in correlating the pharmacokinetic and pharmacodynamic properties of a compound;
Familiarity with in vitro and in vivo safety testing of NCEs.