Principal Scientist, In vivo Pharmacology (Radiopharmaceuticals)

Bicycle Therapeutics

Cambridge, United Kingdom

Job Description

Bicycle Therapeutics is seeking a talented scientist with strong experience of in vivo radiopharmaceutical evaluation to support the preclinical research and discovery efforts for our expanding portfolio of Bicycle -based therapeutics.

You will have a passion for developing transformational treatment paradigms for cancer patients and will enjoy working collaboratively across programs.

This position will report to the Associate Director of In vivo Pharmacology.

Key Responsibilities

Manage the design, execution and interpretation of results from in vivo pharmacology studies to evaluate the activities of Bicycle® Radio Conjugates (BRC™);
Manage in vivo pharmacology research through a network of CROs and academic collaborations;
Effectively collaborate with cross functional disciplines (biology, DMPK, translational sciences, toxicology) and engage internal stakeholders to drive decisions;
Effectively document and communicate results company-wide in diverse settings ranging from project team meetings to internal L&D scientific forums (e.g. science spotlight)
Lead in vivo pharmacology sample management;
Author publications in peer-reviewed journals and represent Bicycle at conferences with scientific presentations in poster or oral formats.

Qualifications

Educated in biological sciences field with extensive industrial experience;
Hands-on experience using multiple types of in vivo oncology models is required;
Experience in the evaluation and development of radiopharmaceuticals is desired;
Experience in radiochemistry and radiolabeling of compounds would be preferred;
Experience in pre-clinical biodistribution and efficacy assessment of radiopharmaceuticals using techniques such as PET and/or SPECT imaging, and ex-vivo biodistribution is required;
A working knowledge of dosimetry would be an advantage;
Some experience in managing external work/collaborations is preferred;
A strong background in cancer biology is preferred;
Capability of working both independently and as part of multiple collaborative and multidisciplinary teams;
Attention to detail and strong interpersonal, organizational and communication skills;
Innovative, entrepreneurial, enjoys working in a fast-paced, small-company environment.