Research Associate/Scientist, Antibody Production Sciences

UCB - Union Chimique Belge

Slough, United Kingdom

We are looking for a skilled protein biochemist to join our small-scale antibody production and automation team as a Research Associate / Scientist in Slough, Berkshire, UK.

About the role

This permanent position involves producing antibody proteins to support all research activities at scales ranging from 2 ml to 200 ml. The ideal candidate will have experience in mammalian cell culture, antibody purification, quality analysis, and automation.

Who you’ll work with

Our Antibody Production Sciences Team (APS) within the Antibody Biology Department of Early Solutions is dedicated to producing and characterizing antibody research reagents to support our innovative research and early development pipeline.

What you’ll do

Perform small-scale transient mammalian transfections and purify expressed monoclonal antibodies using automated techniques;
Organize work effectively and manage time to work on multiple projects;
Interpret data to identify purification and product quality abnormalities, alert stakeholders, and consider possible solutions;
Aid in the development and implementation of automated/robotic high-throughput transient expression and purification technologies;
Maintain diligent record-keeping of experimental methods and results via electronic laboratory notebooks and online registration systems;
Maintain lab equipment to high standards, including assisting with maintenance and cleaning protocols.

Interested?

For this role we’re looking for the following education, experience and skills:

Bachelor’s degree in Biochemistry or Biotechnology;
Fresh graduates with extensive theoretical knowledge of mammalian cell culture, antibody purification, and QC analytics may also be considered;
Practical experience in an industrial setting;
Experience in cell culture, especially with mammalian cell hosts such as CHO & HEK;
Proficiency in aseptic technique and maintenance of cell stocks;
Experience with antibody/protein purification techniques and AKTA Purification platforms;
Familiarity with automated or high-throughput purification platforms and analytical assays (e.g., UPLC/Empower, HPLC/Chemstations);
Competence in protein characterization techniques: Analytical SEC, SDS-PAGE, Western blot, UV-Vis spectroscopy, and Mass spectrometry;
Proficiency in using Excel spreadsheets and logistics databases.

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