Bioinformatician

ProQR Therapeutics

Leiden, Netherlands

Our R&D department is currently looking for an experienced bioinformatician to join our team in Leiden. The bioinformatician will support the wet-lab scientist with the analysis of transcriptomics studies, develops and improves (in silico) analytical methods to accurately understand RNA processing variants in our model systems, and how they are affected by oligonucleotide drugs.

We expect our Bioinformatician to have:

A MSc degree in Bioinformatics with at least 2 years of relevant work experience or a MSc in any scientific field related to biology or chemistry followed by at least 4 years of relevant Bioinformatics work experience;
Experience with Python (must have) and working experience with Pandas and/or Snakemake is a plus;
Experience with NGS with focus on RNA-seq (must have);
Solid knowledge of transcriptomics, RNA biology and/or organic chemistry is a big plus;
Solid knowledge of statistical methods and how to apply them to molecular biology problems;
Experience with predictive models (Scikit-learn and Keras);
Experience with Linux and High-Performance Computing;
Experience with version control systems (Git);
Affinity with finding solutions for uncommon problems and critical about own work;
Passion for innovation and drive to deliver new therapies to patients with high unmet needs.

Key Responsibilities:

You contribute to transcriptomic analyses in the field of RNA therapeutics;
You contribute to develop, maintain, and improve data analysis pipelines, including version control;
You contribute to maintain and curate database systems containing various experimental data types;
You ensure the quality of your analyses by establishing reproducible methods and writing clear documentation;
You work in a multidisciplinary team in close collaboration with wet-lab scientists, technicians, project leads.