Scientist within the Biologics Process Sciences (BPS) Group

UCB - Union Chimique Belge

Braine L'alleud, Belgium

About the Role

The Scientist within the Biologics Process Sciences (BPS) Group will be involved in mid-stage process development and optimization, and clinical/commercial manufacturing support for upstream processes to produce protein therapeutics. This position will primarily focus on the evaluation, development and integration of innovative technologies and processes, and the development an optimization of high productive processes.

The Scientist will manage projects, evaluate products or technologies (e.g. process analytical technologies [PAT] development and integration, automation and micro scale down model development and optimization, etc…), and potentially author sections of regulatory submissions and external publications.

Your role involves mentoring team members, leading projects, and driving the technical and scientific exchange with various departments.

Who You Will Work With

The BPS process development team in various cross-functional project teams and liaise with stakeholders for CMC projects, in a matrix and virtual environment across geographies and time-zones.

You will as well collaborate closely with scientist research, clinical, and commercial manufacturing groups across the globe, forming part of virtual and matrix project teams that span geographies and time zones.

Major Responsibilities

The Scientist working within Biologics Process Sciences will:

Provide technical expertise in upstream processing to Project Teams, supporting technical and scientific exchange across the organization;
Drive innovation to offer cutting-edge process options;
Define the biopharmaceutical processes of the future, potentially leading to patent inventions;
Comply with UCB's Health, Safety & Environment (HSE) policies and actively participate in their enforcement and improvement;
Design, plan, and execute experiments using Quality by Design principles and Design of Experiment methodology;
Document experimental protocols, data, and reports accurately;
Provide cell culture support for technology transfers, process validations, and manufacturing operations;
Serve as the Compliance SME for upstream activities, supporting team members on data integrity standards;
Dedicate at least 70% of their time to laboratory work for cell culture process development, optimization, and scale-up.

Education & Qualification

The ideal candidate will have:

An M.Sc. degree in Biology, Biotechnology, Chemical Engineering, or a related field;
Proven experience in mammalian cell-based therapeutic protein expression and culture systems;
2-6 years of experience in upstream bioprocessing;
Technical expertise in mammalian-cell-based therapeutic protein expression and culture systems;
Knowledge in bioengineering, chemical engineering, statistics, molecular biology, analytical methods, and cellular metabolism;
Strong leadership and team-building skills;
Excellent problem-solving and communication abilities;
Ability to organize and communicate large amounts of data;
Flexibility and the ability to work in a team environment under deadlines;
Good command of spoken and written scientific English; knowledge of French is a plus.

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