The Clinical Trial Oversight Lead oversees out sourced (or CRO) monitoring activities to ensure the quality execution of protocol procedures, adherence to good clinical practices (GCP) and evolving regulatory requirements, and ensure consistency of monitoring activities. Alnylam programs span the globe, often entailing complex protocol procedures and specialty tests, and focus on rare diseases for which access to applicable patient populations may require the involvement of clinical trial sites with limited research experience. The Clinical Trial Oversight Lead will ensure that the CRO monitoring study sites is resulting in the effective identification and problem solving of issues. Findings and solutions will be communicated to both Alnylam and the CRO. The Clinical Trial Oversight Lead will also ensure that the CRO understands complex protocol processes and procedures and may support CRA protocol-specific training.