Senior Scientist - Functional Genomics

Nucleome Therapeutics

Oxford, United Kingdom

The Role

We are seeking a Senior Scientist with expertise in Genomics who is a self-starter, proactive and would like to work in a dynamic environment of a start-up. The successful candidate will investigate the regulation of the non-coding genome in lymphocyte subsets (initially) using state of the art genomics approaches whilst also developing new ones. You will collaborate closely with other experimental and data scientists to guide drug target discovery efforts through interpretation of the Dark Genome’s genetics. As an independent thinker you will plan and implement experiments, interpret the data, and distil complexity into concise communication, while providing scientific coaching and mentorship for less experienced team members. You will have an integral role in the venture, take ownership of the work and demonstrate an exceptional work ethic towards discovering breakthrough medicines that will improve patients’ lives.

What we are looking for

Essential Experience/Skills

PhD in biological discipline, or MSc and demonstrable experience in the fields above;
Demonstrable experience in one or more of the following assays: ATAC-seq, ChIP-seq, RNA-seq and 3C based assays;
Experience and proven-track record in interpreting and generating insights from omics data;
Demonstrable technical expertise in basic molecular biology techniques;
Familiarity with web-based interfaces for genome analysis;
An enthusiasm for and demonstrable knowledge of the key questions and recent developments in gene regulation, epigenetics and the genomics field;
Ability to design research project plans including short-term and long-term experimental plans, needs assessment, prioritise follow-up studies (timelines, costs, deliverables);
Ability to design and run high-quality experiments, interpret data, troubleshoot, and suggest next steps and identify alternative approaches;
Ability to develop and improve new skills and knowledge necessary to successfully support assigned projects;
Proven ability to set up and optimise complex molecular techniques;
Ability to work independently as well as thrive working in a multidisciplinary team;
Strong communication skills and ability to communicate complex ideas to specialists and non-specialists;
Flexible and co-operative approach to colleagues;
Strong organisational and time management skills; ability to work on multiple projects simultaneously, as well as ability to prioritise and balance competing demands;
Ability to deliver high-quality, consistent results in a timely fashion;
A positive “can-do” and result oriented attitude, with openness to new ideas and ability to work flexibly in a highly dynamics environment.

Preferred experience

Experience in pharmaceutical/biotech industry;
Experience in working with primary cell types;
Expertise in disease biology, ideally autoimmune or other immunology-based diseases;
Experience in interpreting population genomics studies e.g. GWAS;
Understanding of drug discovery and development processes;
Proficiency in working in a UNIX based computational environmental;
Ability and willingness to manage people and projects;
Experience supporting and collaborating with computational scientists;
Knowledge and experience in GLP standards.

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